What functions does p53 control?

P53 forms a homotetrameric transcription factor that is reported to directly regulate ~500 target genes, thereby controlling a broad range of cellular processes, including cell cycle arrest, cell senescence, DNA repair, metabolic adaptation and cell death

What does the p53 gene control?

A gene that makes a protein that is found inside the nucleus of cells and plays a key role in controlling cell division and cell death . Mutations (changes) in the p53 gene may cause cancer cells to grow and spread in the body.

Which function of p53 is the most important?

Cell-cycle arrest and apoptosis are the most prominent outcomes of p53 activation. Many studies showed that p53 cell-cycle and apoptosis functions are important for preventing tumor development. p53 also regulates many cellular processes including metabolism, antioxidant response, and DNA repair.

What does p53 do for genes?

The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). This protein acts as a tumor suppressor , which means that it regulates cell division by keeping cells from growing and dividing (proliferating) too fast or in an uncontrolled wa

What are the three major functions of p53?

In normal cells, the p53 protein level is low. DNA damage and other stress signals may trigger the increase of p53 proteins, which have three major functions: growth arrest, DNA repair and apoptosis (cell death) . The growth arrest stops the progression of cell cycle, preventing replication of damaged DNA.

What is the function of the p53 gene and why is it important to the cell cycle?

Activated p53 promotes cell cycle arrest to allow DNA repair and/or apoptosis to prevent the propagation of cells with serious DNA damage through the transactivation of its target genes implicated in the induction of cell cycle arrest and/or apoptosis.

What is the function of p53 and why is it the most common mutation in cancerous tumor cells?

Therefore, p53 is considered the “Guardian of the genome” to prevent accumulation of oncogenic mutations that lead to malignant tumor (1, 2). Mutations in TP53 are found in over half of human cancers, thus is known as the most commonly mutated gene in human cancers (3, 4